diff --git a/.cirrus.yml b/.cirrus.yml
index 2be924a3b6..d778070dc2 100644
--- a/.cirrus.yml
+++ b/.cirrus.yml
@@ -122,7 +122,7 @@ task:
     FILE_ENV: "./ci/test/00_setup_env_native_multiprocess.sh"
 
 task:
-  name: 'macOS 10.12  [GOAL: deploy] [no functional tests]'
+  name: 'macOS 10.14  [GOAL: deploy] [no functional tests]'
   << : *GLOBAL_TASK_TEMPLATE
   container:
     image: ubuntu:bionic
diff --git a/ci/test/00_setup_env_mac.sh b/ci/test/00_setup_env_mac.sh
index e4450a65ce..4a022f9b39 100644
--- a/ci/test/00_setup_env_mac.sh
+++ b/ci/test/00_setup_env_mac.sh
@@ -8,7 +8,7 @@ export LC_ALL=C.UTF-8
 
 export CONTAINER_NAME=ci_macos_cross
 export DOCKER_NAME_TAG=ubuntu:18.04  # Check that bionic can cross-compile to macos (bionic is used in the gitian build as well)
-export HOST=x86_64-apple-darwin16
+export HOST=x86_64-apple-darwin18
 export PACKAGES="cmake imagemagick libcap-dev librsvg2-bin libz-dev libbz2-dev libtiff-tools python3-dev python3-setuptools"
 export XCODE_VERSION=11.3.1
 export XCODE_BUILD_ID=11C505
diff --git a/ci/test/00_setup_env_mac_host.sh b/ci/test/00_setup_env_mac_host.sh
index 7c25a34cfe..906f51fc1a 100644
--- a/ci/test/00_setup_env_mac_host.sh
+++ b/ci/test/00_setup_env_mac_host.sh
@@ -6,7 +6,7 @@
 
 export LC_ALL=C.UTF-8
 
-export HOST=x86_64-apple-darwin16
+export HOST=x86_64-apple-darwin18
 export PIP_PACKAGES="zmq"
 export GOAL="install"
 export BITCOIN_CONFIG="--with-gui --enable-reduce-exports --enable-werror --with-boost-process"
diff --git a/contrib/gitian-descriptors/gitian-osx.yml b/contrib/gitian-descriptors/gitian-osx.yml
index bcfa4c66a2..b30e0c68e9 100644
--- a/contrib/gitian-descriptors/gitian-osx.yml
+++ b/contrib/gitian-descriptors/gitian-osx.yml
@@ -38,7 +38,7 @@ script: |
   set -e -o pipefail
 
   WRAP_DIR=$HOME/wrapped
-  HOSTS="x86_64-apple-darwin16"
+  HOSTS="x86_64-apple-darwin18"
   CONFIGFLAGS="--enable-reduce-exports --disable-bench --disable-gui-tests GENISOIMAGE=$WRAP_DIR/genisoimage"
   FAKETIME_HOST_PROGS=""
   FAKETIME_PROGS="ar ranlib date dmg genisoimage"
diff --git a/depends/README.md b/depends/README.md
index f5a0ec5fb3..0fa6b7c6d6 100644
--- a/depends/README.md
+++ b/depends/README.md
@@ -25,7 +25,7 @@ Common `host-platform-triplets` for cross compilation are:
 - `i686-pc-linux-gnu` for Linux 32 bit
 - `x86_64-pc-linux-gnu` for x86 Linux
 - `x86_64-w64-mingw32` for Win64
-- `x86_64-apple-darwin16` for macOS
+- `x86_64-apple-darwin18` for macOS
 - `arm-linux-gnueabihf` for Linux ARM 32 bit
 - `aarch64-linux-gnu` for Linux ARM 64 bit
 - `powerpc64-linux-gnu` for Linux POWER 64-bit (big endian)
diff --git a/depends/hosts/darwin.mk b/depends/hosts/darwin.mk
index 6099fd4c71..e9faeba336 100644
--- a/depends/hosts/darwin.mk
+++ b/depends/hosts/darwin.mk
@@ -1,4 +1,4 @@
-OSX_MIN_VERSION=10.12
+OSX_MIN_VERSION=10.14
 OSX_SDK_VERSION=10.15.1
 XCODE_VERSION=11.3.1
 XCODE_BUILD_ID=11C505
diff --git a/doc/build-osx.md b/doc/build-osx.md
index 69ee0811f9..7c90cc52aa 100644
--- a/doc/build-osx.md
+++ b/doc/build-osx.md
@@ -130,6 +130,6 @@ tail -f $HOME/Library/Application\ Support/Litecoin/debug.log
 ```
 
 ## Notes
-* Tested on OS X 10.12 Sierra through macOS 10.15 Catalina on 64-bit Intel
+* Tested on OS X 10.14 Mojave through macOS 11 Big Sur on 64-bit Intel
 processors only.
 * Building with downloaded Qt binaries is not officially supported. See the notes in [#7714](https://github.com/bitcoin/bitcoin/issues/7714).
diff --git a/doc/release-notes.md b/doc/release-notes.md
index d032fa8429..e778b75a62 100644
--- a/doc/release-notes.md
+++ b/doc/release-notes.md
@@ -32,12 +32,12 @@ Compatibility
 ==============
 
 Bitcoin Core is supported and extensively tested on operating systems
-using the Linux kernel, macOS 10.12+, and Windows 7 and newer.  Bitcoin
+using the Linux kernel, macOS 10.14+, and Windows 7 and newer.  Bitcoin
 Core should also work on most other Unix-like systems but is not as
 frequently tested on them.  It is not recommended to use Bitcoin Core on
 unsupported systems.
 
-From Bitcoin Core 0.20.0 onwards, macOS versions earlier than 10.12 are no
+From Bitcoin Core 0.22.0 onwards, macOS versions earlier than 10.14 are no
 longer supported. Additionally, Bitcoin Core does not yet change appearance
 when macOS "dark mode" is activated.
 
diff --git a/share/qt/Info.plist.in b/share/qt/Info.plist.in
index c702a78568..ada9a7e9d3 100644
--- a/share/qt/Info.plist.in
+++ b/share/qt/Info.plist.in
@@ -3,7 +3,7 @@
 <plist version="0.9">
 <dict>
   <key>LSMinimumSystemVersion</key>
-  <string>10.12.0</string>
+  <string>10.14.0</string>
 
   <key>LSArchitecturePriority</key>
   <array>