diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index a2b1fe1f24..7c45a5b866 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -194,7 +194,8 @@ chain for " target " development."))
 
 (define (make-nsis-for-gcc-10 base-nsis)
   (package-with-extra-patches base-nsis
-    (search-our-patches "nsis-gcc-10-memmove.patch")))
+    (search-our-patches "nsis-gcc-10-memmove.patch"
+                        "nsis-disable-installer-reloc.patch")))
 
 (define (fix-ppc64-nx-default lief)
   (package-with-extra-patches lief
diff --git a/contrib/guix/patches/nsis-disable-installer-reloc.patch b/contrib/guix/patches/nsis-disable-installer-reloc.patch
new file mode 100644
index 0000000000..4914527e56
--- /dev/null
+++ b/contrib/guix/patches/nsis-disable-installer-reloc.patch
@@ -0,0 +1,30 @@
+Patch NSIS so that it's installer stubs, produced at NSIS build time,
+do not contain .reloc sections, which will exist by default when using
+binutils/ld 2.36+.
+
+This ultimately fixes an issue when running the installer with the
+"Force randomization for images (Mandatory ASLR)" setting active.
+
+This patch has not yet been sent upstream, because it's not clear if this
+is the best fix, for the underlying issue, which seems to be that makensis
+doesn't account for .reloc sections when it builds installers.
+
+The existence of a reloc section shouldn't be a problem, and, if anything,
+is actually a requirement for working ASLR. All other Windows binaries we
+produce contain them, and function correctly when under the same
+"Force randomization for images (Mandatory ASLR)" setting.
+
+See:
+https://github.com/bitcoin/bitcoin/issues/25726
+https://sourceforge.net/p/nsis/bugs/1131/
+
+--- a/SCons/Config/gnu
++++ b/SCons/Config/gnu
+@@ -102,6 +102,7 @@ stub_env.Append(LINKFLAGS = ['-mwindows'])          # build windows executables
+ stub_env.Append(LINKFLAGS = ['$NODEFLIBS_FLAG'])    # no standard libraries
+ stub_env.Append(LINKFLAGS = ['$ALIGN_FLAG'])        # 512 bytes align
+ stub_env.Append(LINKFLAGS = ['$MAP_FLAG'])          # generate map file
++stub_env.Append(LINKFLAGS = ['-Wl,--disable-reloc-section'])
+ 
+ conf = FlagsConfigure(stub_env)
+ conf.CheckCompileFlag('-fno-tree-loop-distribute-patterns')  # GCC 10: Don't generate msvcrt!memmove calls (bug #1248)