diff --git a/ci/test/00_setup_env_mac.sh b/ci/test/00_setup_env_mac.sh
index 0ada280c18..9d6d88a788 100644
--- a/ci/test/00_setup_env_mac.sh
+++ b/ci/test/00_setup_env_mac.sh
@@ -10,8 +10,8 @@ export CONTAINER_NAME=ci_macos_cross
 export DOCKER_NAME_TAG=ubuntu:18.04  # Check that bionic can cross-compile to macos (bionic is used in the gitian build as well)
 export HOST=x86_64-apple-darwin18
 export PACKAGES="cmake imagemagick libcap-dev librsvg2-bin libz-dev libbz2-dev libtiff-tools python3-dev python3-setuptools xorriso"
-export XCODE_VERSION=11.3.1
-export XCODE_BUILD_ID=11C505
+export XCODE_VERSION=12.1
+export XCODE_BUILD_ID=12A7403
 export RUN_UNIT_TESTS=false
 export RUN_FUNCTIONAL_TESTS=false
 export GOAL="deploy"
diff --git a/contrib/gitian-build.py b/contrib/gitian-build.py
index d498c9e2c8..65c8495349 100755
--- a/contrib/gitian-build.py
+++ b/contrib/gitian-build.py
@@ -209,7 +209,7 @@ def main():
     args.macos = 'm' in args.os
 
     # Disable for MacOS if no SDK found
-    if args.macos and not os.path.isfile('gitian-builder/inputs/Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz'):
+    if args.macos and not os.path.isfile('gitian-builder/inputs/Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz'):
         print('Cannot build for MacOS, SDK does not exist. Will build for other OSes')
         args.macos = False
 
diff --git a/contrib/gitian-descriptors/gitian-osx.yml b/contrib/gitian-descriptors/gitian-osx.yml
index 384c2303fb..6cbfef3469 100644
--- a/contrib/gitian-descriptors/gitian-osx.yml
+++ b/contrib/gitian-descriptors/gitian-osx.yml
@@ -34,7 +34,7 @@ remotes:
 - "url": "https://github.com/litecoin-project/litecoin.git"
   "dir": "litecoin"
 files:
-- "Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz"
+- "Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz"
 script: |
   set -e -o pipefail
 
@@ -92,7 +92,7 @@ script: |
   BASEPREFIX="${PWD}/depends"
 
   mkdir -p ${BASEPREFIX}/SDKs
-  tar -C ${BASEPREFIX}/SDKs -xf ${BUILD_DIR}/Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz
+  tar -C ${BASEPREFIX}/SDKs -xf ${BUILD_DIR}/Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz
 
   # Build dependencies for each host
   for i in $HOSTS; do
diff --git a/contrib/guix/README.md b/contrib/guix/README.md
index dffcf99607..1ab68b4938 100644
--- a/contrib/guix/README.md
+++ b/contrib/guix/README.md
@@ -126,10 +126,27 @@ find output/ -type f -print0 | sort -z | xargs -r0 sha256sum
 
 * _**MAX_JOBS**_
 
-  Override the maximum number of jobs to run simultaneously, you might want to
-  do so on a memory-limited machine. This may be passed to `make` as in `make
-  --jobs="$MAX_JOBS"` or `xargs` as in `xargs -P"$MAX_JOBS"`. _(defaults to the
-  value of `nproc` outside the container)_
+  Set the depends tree cache for built packages. This is passed through to the
+  depends tree. Setting this to the same directory across multiple builds of the
+  depends tree can eliminate unnecessary building of packages.
+
+* _**SDK_PATH**_
+
+  Set the path where _extracted_ SDKs can be found. This is passed through to
+  the depends tree. Note that this is should be set to the _parent_ directory of
+  the actual SDK (e.g. SDK_PATH=$HOME/Downloads/macOS-SDKs instead of
+  $HOME/Downloads/macOS-SDKs/Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers).
+
+* _**JOBS**_
+
+  Override the number of jobs to run simultaneously, you might want to do so on
+  a memory-limited machine. This may be passed to:
+
+  - `guix` build commands as in `guix environment --cores="$JOBS"`
+  - `make` as in `make --jobs="$JOBS"`
+  - `xargs` as in `xargs -P"$JOBS"`
+
+  _(defaults to the value of `nproc` outside the container)_
 
 * _**SOURCE_DATE_EPOCH**_
 
diff --git a/contrib/macdeploy/README.md b/contrib/macdeploy/README.md
index 64fcfcd1d4..8011c5f19d 100644
--- a/contrib/macdeploy/README.md
+++ b/contrib/macdeploy/README.md
@@ -17,9 +17,9 @@ When complete, it will have produced `Litecoin-Qt.dmg`.
 ### Step 1: Obtaining `Xcode.app`
 
 Our current macOS SDK
-(`Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz`) can be
+(`Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz`) can be
 extracted from
-[Xcode_11.3.1.xip](https://download.developer.apple.com/Developer_Tools/Xcode_11.3.1/Xcode_11.3.1.xip).
+[Xcode_12.1.xip](https://download.developer.apple.com/Developer_Tools/Xcode_12.1/Xcode_12.1.xip).
 An Apple ID is needed to download this.
 
 After Xcode version 7.x, Apple started shipping the `Xcode.app` in a `.xip`
@@ -31,25 +31,25 @@ approach (tested on Debian Buster) is outlined below:
 apt install cpio
 git clone https://github.com/bitcoin-core/apple-sdk-tools.git
 
-# Unpack Xcode_11.3.1.xip and place the resulting Xcode.app in your current
+# Unpack Xcode_12.1.xip and place the resulting Xcode.app in your current
 # working directory
-python3 apple-sdk-tools/extract_xcode.py -f Xcode_11.3.1.xip | cpio -d -i
+python3 apple-sdk-tools/extract_xcode.py -f Xcode_12.1.xip | cpio -d -i
 ```
 
 On macOS the process is more straightforward:
 
 ```bash
-xip -x Xcode_11.3.1.xip
+xip -x Xcode_12.1.xip
 ```
 
-### Step 2: Generating `Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz` from `Xcode.app`
+### Step 2: Generating `Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz` from `Xcode.app`
 
-To generate `Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz`, run
+To generate `Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz`, run
 the script [`gen-sdk`](./gen-sdk) with the path to `Xcode.app` (extracted in the
 previous stage) as the first argument.
 
 ```bash
-# Generate a Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz from
+# Generate a Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz from
 # the supplied Xcode.app
 ./contrib/macdeploy/gen-sdk '/path/to/Xcode.app'
 ```
@@ -80,7 +80,7 @@ and its `libLTO.so` rather than those from `llvmgcc`, as it was originally done
 
 To complicate things further, all builds must target an Apple SDK. These SDKs are free to
 download, but not redistributable. To obtain it, register for an Apple Developer Account,
-then download [Xcode_11.3.1](https://download.developer.apple.com/Developer_Tools/Xcode_11.3.1/Xcode_11.3.1.xip).
+then download [Xcode_12.1.xip](https://download.developer.apple.com/Developer_Tools/Xcode_12.1/Xcode_12.1.xip).
 
 This file is many gigabytes in size, but most (but not all) of what we need is
 contained only in a single directory:
diff --git a/depends/hosts/darwin.mk b/depends/hosts/darwin.mk
index 9173570e0d..acf52f7e25 100644
--- a/depends/hosts/darwin.mk
+++ b/depends/hosts/darwin.mk
@@ -1,7 +1,7 @@
 OSX_MIN_VERSION=10.14
-OSX_SDK_VERSION=10.15.1
-XCODE_VERSION=11.3.1
-XCODE_BUILD_ID=11C505
+OSX_SDK_VERSION=10.15.6
+XCODE_VERSION=12.1
+XCODE_BUILD_ID=12A7403
 LD64_VERSION=609
 
 OSX_SDK=$(SDK_PATH)/Xcode-$(XCODE_VERSION)-$(XCODE_BUILD_ID)-extracted-SDK-with-libcxx-headers