diff --git a/doc/release-notes.md b/doc/release-notes.md
index 53b5a2119f3..c21a153a250 100644
--- a/doc/release-notes.md
+++ b/doc/release-notes.md
@@ -262,6 +262,12 @@ Graphical User Interface (GUI)
   balance shown if the wallet was created using the `createwallet` RPC
   and the `disable_private_keys` parameter was set to true.
 
+- The launch-on-startup option is no longer available on macOS if
+  compiled with macosx min version greater than 10.11 (use
+  CXXFLAGS="-mmacosx-version-min=10.11"
+  CFLAGS="-mmacosx-version-min=10.11" for setting the deployment
+  sdk version)
+
 Low-level changes
 =================
 
diff --git a/src/qt/guiutil.cpp b/src/qt/guiutil.cpp
index b84c07d51ab..b61fc25dc7d 100644
--- a/src/qt/guiutil.cpp
+++ b/src/qt/guiutil.cpp
@@ -683,7 +683,7 @@ bool SetStartOnSystemStartup(bool fAutoStart)
 }
 
 
-#elif defined(Q_OS_MAC)
+#elif defined(Q_OS_MAC) && defined(MAC_OS_X_VERSION_MIN_REQUIRED) && MAC_OS_X_VERSION_MIN_REQUIRED <= 101100
 // based on: https://github.com/Mozketo/LaunchAtLoginController/blob/master/LaunchAtLoginController.m
 
 LSSharedFileListItemRef findStartupItemInList(LSSharedFileListRef list, CFURLRef findUrl);
diff --git a/src/qt/optionsdialog.cpp b/src/qt/optionsdialog.cpp
index 27cec06d4bb..849bc2e4771 100644
--- a/src/qt/optionsdialog.cpp
+++ b/src/qt/optionsdialog.cpp
@@ -74,6 +74,12 @@ OptionsDialog::OptionsDialog(QWidget *parent, bool enableWallet) :
 #ifdef Q_OS_MAC
     /* remove Window tab on Mac */
     ui->tabWidget->removeTab(ui->tabWidget->indexOf(ui->tabWindow));
+#if  defined(MAC_OS_X_VERSION_MIN_REQUIRED) && MAC_OS_X_VERSION_MIN_REQUIRED > 101100
+    /* hide launch at startup option if compiled against macOS > 10.11 (removed API) */
+    ui->bitcoinAtStartup->setVisible(false);
+    ui->verticalLayout_Main->removeWidget(ui->bitcoinAtStartup);
+    ui->verticalLayout_Main->removeItem(ui->horizontalSpacer_0_Main);
+#endif
 #endif
 
     /* remove Wallet tab in case of -disablewallet */